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KMID : 0043319990220060642
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Archives of Pharmacal Research
1999 Volume.22 No. 6 p.642 ~ p.645
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Anti-allergic Components from the Peels of Citrus nushiu
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Kim Dae-Keun
Lee Ki-Taek
Eun Jae-Soon
Zee Ok-Pyo
Lim Jong-Pil
Eum Sang-Sup
Kim Sang-Hyun
Shin Tae-Yong
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Abstract
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In a bioassay-guided search for anti-allergic compounds from higher plants of Korea, poly-methoxyflavones, 3’,4’,5,6,7,8-hexamethoxyflavone (I), 5-hydroxy-3’,4’,6,7,8-pentamethoxyflavone (II) and 3’,4’,5,7,8-pentamethoxyflavone (III) have been isolated from the immature peels of Citrus unshiu. Structures of these compounds were elucidated on the basis of spectroscopic techniques. Compounds I and II inhibited dose-dependent histamine release from the rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE.
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KEYWORD
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Anti-allergic effect, Citrus unshiu, 3’, 4’, 5, 6, 7, 8-Hexamethoxyflavone, 5-Hydroxy-3’, 4’, 6, 7, 8-pentamethoxyflavone, Compound 48/80, Anti-DNP IgE
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